抗真菌T细胞在肺内应答及其如何经肠肺轴

Anti-fungalTcellresponsesinthelungandmodulationbythegut-lungaxis.

抗真菌T细胞在肺内应答及其如何经肠-肺轴调节

Abstract

Thelungisacentralorganforimmune-environmentalinteractionsrangingfromtoleranceagainstharmlesssubstancestoprotectionagainstpathogens,whichareparticularlysensitivetoregulationbytheintestinalmicrobiota.Airbornefungi,cancausevarietyofdiseases,includingallergiesandinflammatorydisorders,aswellaslife-threateninginvasiveinfections.Remarkabledifferencesexistbetweenubiquitousfungalspecieswithregardtoprotectiveimmunemechanisms.RecentdatahavesurprisinglyidentifiedAspergillus-specificregulatoryTcellsasanessentialtolerancecheckpointandprovidedmechanisticinsightforthelossoftoleranceinthecourseofimmunepathologies.Furthermore,pathogenicTh17cellsinAspergillus-associatedinflammatorydiseaseseemtobeinducedbycross-reactivitytotheintestinal